In contrast, none of 17 IGHV2/IGHV3 B-CLL (p = 0.027; Fisher's exact test), or 20 normal control samples (p = 0.022; Fisher's exact test) reacted with HIV-1 Env antigens (Figure S1 and Figure S2). This evidence concerns the gene ERVW-1 and B-cell chronic lymphocytic leukemia.