Most (69%) had >25% of the liver volume effected by tumor and/or pre-existing liver dysfunction (41% albumin <35 g/L; 14% total bilirubin >1.2 mg/dL); 7 (24%) had received prior liver-directed therapy (resection, RFA, TACE or 131I-lipiodol). The gene discussed is ALB; the disease is Decreased liver function.