Cu enters the cell through the high affinity Cu transporter CTR1 [19], and once inside the cell, it is handled by acceptor-specific Cu-chaperones including Cu chaperone for SOD1 (CCS) that delivers Cu to cytosolic SOD1, COX17 that transfers Cu to mitochondrial cytochrome, and ATOX1 that delivers Cu to ATPases, ATP7A and ATP7B, also known as Menkes and Wilson disease proteins, respectively [20]. This evidence concerns the gene SOD1 and Wilson disease.