Recent studies have highlighted the prognostic relevance of measures of kidney function (eg, estimated glomerular filtration rate [eGFR]) and albuminuria (eg, urine albumin-creatinine ratio [ACR]).2, 3 Lower eGFR and higher ACR values are associated independently with increased risks of cardiovascular mortality, all-cause mortality, and end-stage renal disease (ESRD; ie, the need for dialysis or transplantation).2, 3, 4 Recent international guidelines recommend classifying CKD based on cause, eGFR, and ACR.5 The gene discussed is ALB; the disease is chronic kidney disease.