Several other genes in our severity panel are involved in cell cycle and proliferation, for example, KLF9, CCND3, YIPF5, ALG10B, and ARID5A. Taken together this literature shows well-established pathogenic roles in sepsis or other inflammatory conditions for much of our candidate biomarker panel and constitutes an external validation of our reporter assay system. This evidence concerns the gene YIPF5 and Sepsis.