It has been established that the common deafness mutations for the Chinese population are GJB2 c.235delC, c.299-300delAT, c.176-191del16, c.35delG; GJB3 c.538C > T; SLC26A4 c.IVS7-2A > G, c.2168A > G; and mitochondrial m.1555A > G and m.1494C > T [8,10], whereas the major mutations in the south Chinese population consist of GJB2 c.235delC, c.109G > A, c.299-300delAT, c.176-191del16; SLC26A4 c.IVS7-2A > G and c.1229 T > C; and mitochondrial m.1555A > G. The gene discussed is GJB3; the disease is deafness.