RNF43 and cancer: By applying cDNA microarray technology coupled with laser micro-dissection, we had identified three oncoantigens, ring finger protein 43 (RNF43) [4], 34 kDa-translocase of the outer mitochondrial membrane (TOMM34) [5], and KOC1 (IMP-3; IGF-II mRNA binding protein 3) [6,7], as targets for development of cancer peptide vaccines for CRC.