TNF and neoplasm: Blocking of TNF-α during the co-culture of macrophages and tumor cells by the soluble TNF receptor etanercept combined with the TNF-α neutralizing antibody adalimumab did not prevent the inhibition of cell growth of HOS-143b and OHS cells by LPS + IFN-γ–activated M1-like macrophages or supernatants derived from these macrophages (Figure 4, panel D and data not shown).