CP and infection: Consistent with our preliminary findings in the CP FH84 and TV DE37 [36], phylogenetic tree analysis of env V3-V5 sequences in the first viral RNA positive plasma samples of the ivg-infected animals shows that those from the TV, CP and RP macaques intermingled (Figure 3A), suggesting that the differences in viral replication and disease progression among these three groups of animals cannot be explained by transmission/infection with specific genotypic variants.