Following the treatment of the undifferentiated human neuroblastoma cell line SH-SY5Y with either 24-OH or 27-OH, both employed at 5 μm final concentration, a significant doubling of α-secretase and down-regulation of β-secretase (BACE1) activities occurred in the presence of 24-OH, whereas 27-OH-treated cells behaved like controls (Famer et al., 2007). Here, BACE1 is linked to neuroblastoma.