For example, there is evidence for changes in Cx43 phosphorylation state under ischemia in the heart (Solan et al., 2007; Solan and Lampe, 2009; Miura et al., 2010; Jeyaraman et al., 2012; Marquez-Rosado et al., 2012), and opening of HCs seems to have a role in cardiomyocyte damage in ischemia (John et al., 1999; Li and Nagy, 2000; Li et al., 2001; Contreras et al., 2002; Vergara et al., 2003b; Shintani-Ishida et al., 2007; Hawat et al., 2010). This evidence concerns the gene GJA1 and ischemia.