Aberrant methylation status of NR2B promoter was present in more than 60 % of human gastric and non-small cell lung carcinoma samples, whereas the GRIN2B methylation status alterations were found in no more than 5 % of corresponding normal tissues (Liu et al. 2007; Tamura et al. 2011). The gene discussed is GRIN2B; the disease is non-small cell lung carcinoma.