For thyroid cancer, our results remarkably show that hsa-miR-221/222 are overexpressed, consistent with the previous finding (3), and significantly downregulate a large cohort of genes including oncogenes ARID1A, ARNT, BCL11B, DICER1, ELK4, TCF12, TCF7L2, ARID1A, ARNT, BCL11B, DICER1, ELK4, TCF12 and TCF7L2 (Figure 8). This evidence concerns the gene TCF12 and thyroid cancer.