While some studies report the associations between the co-expression of HER-2/HER-4 or HER-3/HER-4 and late tumour stages [21], [22], to our knowledge the significant co-expression of EGFR/HER-4 with poorer disease-free survival in colon cancer patients has not been previously reported. Here, ERBB3 is linked to malignant colon neoplasm.