AQP4 and Febrile seizure (within the age range of 3 months to 6 years): Heuser and colleagues (2010) showed that a combination of three single nucleotide polymorphisms (SNPs) in the AQP4 gene (encoding a water channel), together with two SNPs in the KCNJ10 gene, was associated with mTLE. Association analysis in patients with a history of febrile seizures (mTLE-FS) revealed that a combination of SNPs in KCNJ10, AQP4, and the area between KCNJ10 and KCNJ9 was associated with mTLE-FS (Heuser and others 2012).