As SCD results in the release of pro-oxidative factors that have the potential to artificially increase p-HDL levels, it seemed reasonable to develop a new method for quantifying p-HDL free from the pro-oxidant effects of cf Hb, XO/X and albumin which is typically considered an antioxidant but when it binds lipid hydroperoxides or heme it can actually increase lipid peroxidation. The gene discussed is GSTM1; the disease is Schnyder corneal dystrophy.