An immunomonitoring of 17 patients with pancreatic cancer from the CapRI-2 study, and tumor-bearing mice treated with combination of chemo (radio) therapies with IFN was performed and immunological effects of IFN and chemo-radio-immunotherapy with IFN and 5-FU were analyzed in this study. This evidence concerns the gene IFNA1 and familial pancreatic carcinoma.