With the purpose of exploring the potential relationship between the expression of LDH-A and the prognosis in different types of GC, we assessed the survival of patients in different subgroups: When statistical analysis was performed stratified by Lauren grade and histological classification, significance appeared in diffuse type GC and undifferentiated type GC (P<0.001, respectively), but not in intestinal (P = 0.179) or differentiated (P = 0.104) ones. The gene discussed is LDHA; the disease is gastric cancer.