CYCS and hepatocellular carcinoma: Consistent with our study, it has been reported that knocking down the expression of LDH-A in human hepatocellular carcinoma cells could induce apoptosis [8], and downregulation of LDH-A could increase the production of ROS and cytosolic Ca2+ signaling, which decreased the inner mitochondrial membrane potential and led to the release of cytochrome C in hepatocellular carcinoma cells.