LDHA and metastatic malignant neoplasm in the lymph nodes: As summarized in Table 2, We found that increased expression of LDH-A was significantly associated with age of patients (P = 0.004) and histological type (P = 0.02), lymph node metastasis (P = 0.043), but not with gender (P = 0.072), tumor size (P = 0.086), depth of invasion (P = 0.328), lymphatic invasion(P = 0.738), lauren grade (P = 0.152) or TNM stage (P = 0.417).