LDHA and metastatic malignant neoplasm in the lymph nodes: Table 3 shows the significance: Adjusted for other covariates, the results from the multivariate analysis showed that LDH-A expression (P<0.001), lymphatic invasion (P = 0.046) and Lauren grade (P = 0.001), TNM stage (P = 0.006), but not age (P = 0.053), tumor size (P = 0.111), depth of invasion (P = 0.598), lymph node metastasis (P = 0.089), or histological type (P = 0.674), were independent prognostic risk factors for OS (Table 3).