Furthermore, inhibition of the migration and invasion abilities of MDA-MB-231 and MDA-MB-435 metastatic breast cancer cell lines upon ectopic overexpression of DBC2 was associated with increased protein expression of breast cancer metastasis suppressor BRMS1 and decreased phosphorylation of ezrin, a key signaling molecule that regulates cell migration and invasion [33]. This evidence concerns the gene RHOBTB2 and breast cancer.