After further adjustment for all relevant genetic polymorphisms (apoE2, ApoE4, CFH Y402H, ARMS2 A69S, LIPC rs10468017, LIPC rs493258, LPL rs12678919, ABCA1 rs1883025 and CETP rs3764261), higher HDL remained significantly associated with an increased risk of early (OR = 2.45, P = 0.0002) or any AMD (OR = 2.29, P = 0.0003). The gene discussed is CFH; the disease is age-related macular degeneration.