Multivariate Cox analysis showed that vascular invasion, tumor size, TNM stage and intratumoral Nova1 was significantly associated with OS (P = 0.036, 0.044, 0.013, and 0.025, respectively), while tumor size, tumor number and intratumoral Nova1 levels was similarly associated with TTR (P = 0.007 and 0.002, respectively; Table 3). Here, TTR is linked to neoplasm.