On the other hand, the histology of the PD lesions was substantially distinguished between WT, Ncf1−/− and GPx1−/− mice; epidermal thickening and elongation of rete ridges were more prominent, hyperkeratosis and parakeratosis were exaggerated and parakeratotic microabscesses were often observed, vascular dilatation and inflammatory cell infiltration were more prominent in dermis of PD in Ncf1−/− mice; whereas all the pathological findings of PD were less prominent in GPx1−/− mice. This evidence concerns the gene GPX1 and Hyperkeratosis.