In this regard, it is worth noting that, of the 2 LOAD patients carrying p.V236E, one developed dementia at an advanced age (98 yrs, APOE ε3a/ε3b genotype) and the other, who was diagnosed at 68, also carried an ε4 allele (APOE ε3b/ε4 genotype), which likely counters the protection afforded by p.V236E. This evidence concerns the gene APOE and dementia.