Comparison of the 95% CI for APOE ε3b (OR = 0.10, 0.02 to 0.35) with that for APOE ε2 (OR = 0.46, 0.38 to 0.54), indicates that, in our series, the ε3b allele reduced risk of AD as much or more than the APOE ε2 allele (Table 2, Multivariate Logistic Regression). Here, APOE is linked to Alzheimer disease.