In good agreement with these findings, systemic or i.t. administration of Nav1.8 selective blockers (e.g., A-803467) was found to be active in reducing various nociceptive symptoms and to potently inhibit evoked and spontaneous firing of dorsal horn wide dynamic range neurons in inflammatory and neuropathic pain models [28,70,74,79,80]. The gene discussed is SCN10A; the disease is neuropathic pain.