It has been reported that STC2 expression was upregulated in various tumors, including breast cancer [16,17], prostate cancer [18], esophageal squamous cell carcinoma (ESC) [19], gastric cancer [20], colorectal cancer [21], renal cell carcinoma (RCC) [22] and neuroblastoma [23]. The gene discussed is STC2; the disease is hereditary clear cell renal cell carcinoma.