Collectively, these data strongly suggest that reduced coverage of pericytes in tumor vessels might be another main origin of the increased vascular tumor leakage observed in platelet-depleted mice.To better investigate the molecular mechanisms by which platelet depletion induced vessel leakage in the tumor microenvironment, we evaluated the expression of VE-cadherin protein, which is a critical EC-specific adhesion molecule in regulating vascular permeability. The gene discussed is CDH5; the disease is neoplasm.