In comparison, an similar findings were found in microdialysates and tumor samples in which the TGF-β1 level of PLT-depletion was significantly lower than in control and co-implantation mice (Figure 6B and C).To better investigate the molecular mechanisms by which platelet depletion reduces metastasis in the tumor microenvironment, we further evaluated the expression of proteins that are involved in regulating the basal membrane and barrier cancer cell intravasion. This evidence concerns the gene TGFB1 and cancer.