Each DNL-Rap conjugate (Table 1) was obtained with a general protocol involving (i) expression of the respective IgG-AD2 module in myeloma cells, with purification by protein A-based MabSelect affinity chromatography; (ii) expression of Rap-DDD2 in E. coli as inclusion bodies, purified by immobilized metal affinity chromatography under denaturing conditions, and subsequently refolded; (iii) combination of IgG-AD2 with Rap-DDD2 under redox conditions; and (iv) purification of the resulting DNL-Rap conjugate by MabSelect chromatography. This evidence concerns the gene POFUT1 and plasma cell myeloma.