The mechanisms underlying the downregulation of TGFβR2 expression in cancer cells have been investigated, showing that repressed expression of TGFβR2 in microsatellite instability-high colorectal cancer and esophageal adenocarcinoma involves hypermethylation of the TGFβR2 promoter region [11,12]. The gene discussed is TGFBR2; the disease is colorectal cancer.