However, TGFβR2 promoter methylation is not frequent in some cancers such as Head and neck squamous cell carcinoma (HNSCC) (11.4%) [13], although there is a frequent loss of TGFβR2, suggesting that other mechanisms may contribute to the downregulation of TGFβR2 expression. This evidence concerns the gene TGFBR2 and head and neck squamous cell carcinoma.