RNPC3 and systemic lupus erythematosus: Zona pellucida antibodies are associated with POI, antibodies to double-stranded DNA (ds-DNA), histone, nuclear ribonucleoprotein (RNP) and Smith antigen [5] are associated with SLE, whereas antibodies to Sjogren’s syndrome A (SSA/Ro) and Sjogren’s syndrome B(SSB/La) can occur in both SLE and Sjogren’s syndrome (SS).