Surprisingly, among all the 277 KEGG pathways, a large number of DEGs are distributed in “pathways in cancer”, “insulin signaling”, and “MAPK signaling pathway” (Additional file 1: Figure S1, Additional file 2: Figure S2 and Additional file 3: Figure S3), which rank on the top 3, 9, and 15 KEGG pathways containing 49, 35, and 32 DEGs, respectively (Table 4). Here, INS is linked to cancer.