In order to better understand the molecular mechanism(s) of the triple therapeutic association SeR-Se-Ly on apoptosis, we studied the effects of SeR, Se and Ly, alone or in association, on the expression of four IAPs, cIAP-1, cIAP-2, NAIP and survivin in rats with experimental testosterone-dependent BPH. This evidence concerns the gene BIRC5 and benign prostatic hyperplasia.