TSC1 and tuberous sclerosis: In the light of this considerations, our findings in TSC2−/meth ASM cells [16] and LAM/TSC cells indicate that different epigenetic signatures related to closed chromatin conformation can affect TSC2 and may be crucial in the development of TSC lesions because they lead to the absence of tuberin expression as it is caused by the deletion of the wild-type allele in TSC2−/− ASM cells.