Identical TSC2 mutations and loss of heterozygosity (LOH) patterns were found in LAM cells from lung nodules, angiomyolipomas (AMLs) and lymph nodes of the same sporadic LAM patient, suggesting that the two diseases share a common genetic origin; this is also consistent with metastatic spread among organs [7,8]. The gene discussed is TSC2; the disease is angiomyolipoma.