Before adjustment, strong positive relationships were seen between BMD and sclerostin (β represents SD change in sclerostin per SD increase in BMD) measured at L1 (0.32 [0.22, 0.43]), the total hip (0.25 [0.15, 0.35]) and TB (0.26 [0.16, 0.37]) (P < .001 for all). The gene discussed is SOST; the disease is tuberculosis.