In fact, a recently published phase I study in patients with melanoma that combined anti-CTLA-4 (ipilimumab) and anti-PD1(nivolumab) mAbs resulted in a rapid and deep tumor regression in a substantial proportion of patients (53% of patients had an objective response, all with tumor reduction of 80% or more) (74). This evidence concerns the gene CTLA4 and neoplasm.