CSF2 and neoplasm: The most advance of these, Talimogene laherparepvec (T-VEC, formerly OncoVex or JS1/ICP34.5-/ICP47-/GM-CSF; an HSV isolate selected for its potency over laboratory strains, it is deleted in both the ICP34.5 and ICP47 genes to further increase viral replication and tumor cell killing, it also expresses human GM-CSF for immune stimulation) has demonstrated some very promising clinical data.