TGF-β is a pleiotropic cytokine that possess either inflammatory or regulatory properties depending on the cellular and environmental context (100); however, TGF-β can mediate immune suppression by indirect mechanisms, for example, increasing ARG1 activity and decreasing iNOS expression that limits macrophage-dependent cytostasis of fibrosarcoma cells (101). The gene discussed is TGFB1; the disease is fibrosarcoma.