NOS2 and melanoma: This phenolic compound can be considered more than just an oxidant scavenger molecule since it inhibits the NF-κB activation reducing iNOS and DNA-dependent protein kinase catalytic subunit levels; additionally curcumin induces the up-regulation of p21, p27, p53, and the checkpoint kinase 2 expression, thus promoting the G2/M cycle arrest and apoptosis in human melanoma cell lines (179).