SCN1A and autism: Other examples of mouse models to study characteristics of ASD include Purkinje-specific knock out of TSC1 (Tsai et al., 2012), chromosome-engineered mouse model for human 15q11-13 (Nakatani et al., 2009), model for 16p11.2 lesion found in autism (Horev et al., 2011), 22q11.2 mice lacking PTEN (Zhou et al., 2009), CNTNAP2 (Penagarikano et al., 2011), SHANK2 (Won et al., 2012), and SCN1A (Han et al., 2012).