Some of the mouse models representing syndromic forms of ASD include mice modeling Phelan–McDermid syndrome (SHANK3; Bangash et al., 2011; Peca et al., 2011a), Rett syndrome (MeCP2; Shahbazian et al., 2002; Moretti et al., 2006), fragile X syndrome (FMR1; Ronesi et al., 2012), Timothy syndrome (TS; CACNA1C; Bader et al., 2011), and others (see also Table 2). This evidence concerns the gene SHANK3 and Timothy syndrome.