The importance of TRPM4 in disease has been underlined by the observation that many pathogenic genetic variants have been found in patients with cardiac conduction disorders (Abriel et al., 2012), and that TRPM4 knock-out mice develop less neurological alterations in a mouse model of multiple sclerosis (Schattling et al., 2012). The gene discussed is TRPM4; the disease is heart conduction disease.