Moreover, the inhibitory effect of rapamycin on expression of RhoA is also observed in other tumor cell lines, including those derived from cervical cancer (HeLa), prostate cancer (PC-3), Ewing sarcoma (Rh1), and glioblastoma (U-373) [26], suggesting that this is not cell-type dependent. The gene discussed is RHOA; the disease is prostate carcinoma.