PSIP1 and cancer: We show that (i) the maintenance of intracellular LEDGF amounts in HPV-positive tumor cells is critically dependent on continuous HPV E6/E7 expression, (ii) HPVs can transcriptionally stimulate LEDGF gene expression via LEDGF promoter activation, (iii) LEDGF is crucial for the growth and survival of HPV-positive cancer cells following DNA damage, and (iv) LEDGF levels are significantly elevated in cervical dysplasias and cancers.