PM inhibited p-Akt and its downstream targets Foxo-3α and cyclin D1; NF-κB (p65) and NF-κB-regulated Cox-2 and VEGF; p-mTOR and mTOR-regulated p-S6K1 and p-4E-BP1 in both pancreatic cancer cell lines. The gene discussed is EIF4EBP1; the disease is familial pancreatic carcinoma.