MMP1 and mitral valve disorder: Thus the likelihood of presenting severe mitral valve disease of rheumatic originwas 9.32 times higher for subjects with PICP values >459 ng/ml, 4.59 times higher for subjects with PIIINP values >351 ng/ml, 4.72 times higher for subjects with MMP-1 values >21.8 ng/ml and 2.35 times higher for subjects with TIMP-1 values >105 ng/ml (Table 3).