The relevance of the IL-1 pathway in aspergillosis is underscored by the fact that polymorphisms IL-1 gene cluster polymorphisms are associated with susceptibility to develop in invasive pulmonary aspergillosis [18], and that dectin-1 knockout mice display increased fungal burden and mortality during invasive aspergillosis, which is dependent on IL-1 [19]. This evidence concerns the gene IL1B and aspergillosis.