Thus, it is recognized that pDCs are the major source of IFN-α [63], [64], [104], [105] and that type I interferon could lead to increased synthesis of other innate immune factors such as tetherin that inhibit viral release and also are known to sense viral infection and activate NFkB anti-inflammatory pathway contributing to control of virus replication [106]. The gene discussed is BST2; the disease is viral infectious disease.