Neurotrophins (Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), and Neurotrophin-3 (NT-3)), as well as their cell surface receptors (p75, TrkA, TrkB, and TrkC) are validated targets for therapeutics in a variety of pathologies ranging from cancer to neurodegeneration [1]–[4]. The gene discussed is NGF; the disease is cancer.