In the three-factor analysis, the gene expression of key genes or proteins discussed in our manuscript (i.e. TNF-α, IL-1β, IL-6, cytokeratins, PLAC8, CXCL12, PECAM1, LAMB3, SCEL, DSG2) had the same up- or downregulation regardless of chorioamnionitis with the exception of MMP1. MMP1 gene expression was upregulated in GBS animals without chorioamnionitis, but similar to controls in the two animals with chorioamnionitis. Here, PLAC8 is linked to chorioamnionitis.