We have previously disclosed that SOCE, activated upon either passive (e.g. CPA-induced) or InsP3-dependent depletion of ER Ca2+ reservoir, is up-regulated in RCC-ECFCs as compared to N-ECFCs due to the over-expression of Stim1, Orai1 and TRPC1 [23]. This evidence concerns the gene ORAI1 and renal cell carcinoma.