An additional example of the variability in the composition of the Ca2+ machinery encountered in ECFCs is provided by umbilical cord derived-cells (UCB-ECFCs): these cells lack InsP3R1 and express TRPC3, a diacylglycerol (DAG)-gated Ca2+-permeable channel which is absent in both N- and RCC-ECFCs [18], [23], [27]. This evidence concerns the gene ITPR1 and renal cell carcinoma.