ANGPT1 and infection: To further examine whether the elevated levels of Ang-1 observed in rosiglitazone-treated mice directly contributed to improved survival and neuroprotection we infected mice that were either sufficient for Ang-1 or had one Ang-1 allele deleted (Ang-1del, the kind gift of Dr. SE Quaggin [20]) with PbA and treated them with artesunate plus either rosiglitazone or saline as a control starting on day 5.5 post-infection.