So far, several gene polymorphisms have been demonstrated to be associated with the risks of T1DM, including the human lymphocyte antigen (HLA) gene, the regulatory region of the insulin gene and the interleukin-1 receptor type 1 (IL1R1) gene, cytotoxic T lymphocyte associated-4 (CTLA-4) gene and the vitamin D receptor (VDR) gene. Here, IL1R1 is linked to type 1 diabetes mellitus.