In another interesting experiment Saha and co-workers reported that in case of mouse skin carcinogenesis model, amarogentin curtailed the tumour progression by downlegulating the expression of COX-2 and agonistically influencing the apoptotic mechanism governed by Caspase-3, with an IC50 of 0.5 mg, though, the maximum activity was observed at a concentration of 0.2 mg/mouse, much lower than the estimated IC50[42]. The gene discussed is PTGS2; the disease is neoplasm.