These experimental results are in agreement with our human data, where T2D islets show impaired glucose-stimulated insulin secretion in parallel with increased expression and decreased DNA methylation of CDKN1A and PDE7B. Together, our experimental and human data support a model where diabetes associated epigenetic modifications may lead to altered gene expression and subsequently impaired insulin secretion. The gene discussed is INS; the disease is type 2 diabetes mellitus.