Moreover, among the candidate genes for T2D and obesity shown in Table 3, there was elevated DNA methylation in β-cells compared with human islets for three CpG sites at P<0.05 (cg26979504 in HHEX, cg03257822 in HMGA2 and cg04920032 in FAIM2). This evidence concerns the gene HMGA2 and obesity due to melanocortin 4 receptor deficiency.